Outcome of Stem Cell Transplantation in Patient with Spinal Cord Injury: A Systematic Review

Spinal cord injury (SCI) is well known as a severely disabling that can result in long-term neurological impairment and great impact on the social economic aspects of patients. To investigate controversy regarding Stem Cell Transplantation treatment modality to alleviate devastating effect Cord Injury, we performed literature research according PRISMA guidelines through Pubmed, Cochrane, EMBASE Library find studies about SCI its stem cell management October 20th, 2020 with keywords "stem transplantation" OR "spinal mesenchymal cell" "treatment" AND injury" "traumatic spinal injury") "outcome“. The search was filtered include clinical human last 5 years' publication period written English only. A total 15 non-duplicate citations were found. 14 articles remained after title abstract screening. Ten are excluded from this study because they do not contain any outcomes interest. Four selected for systematic review. 72 patients included review 4 prospective cohort studies. Most classified their status based ASIA (American Injury Association) classification quantifying severity. In conclusion, transplantation yielded satisfactory results comparison conventional Future longer terms should be cement validity finding.